C03: Translate a SNOMED-CT concept into a MedDRA concept

This query accepts a SNOMED-CT concept ID as input and returns details of the equivalent MedDRA concepts.

The relationships in the vocabulary associate MedDRA ‘Preferred Term’ to SNOMED-CT ‘clinical findings’. The respective hierarchy for MedDRA and SNOMED-CT can be used to traverse up and down the hierarchy of each of these individual vocabularies.
Also, not all SNOMED-CT clinical findings are mapped to a MedDRA concept in the vocabulary.

Input:
 Parameter  Example  Mandatory  Notes
 SNOMED-CT Concept ID  312327  Yes Concept Identifier for ‘Acute myocardial infarction’
 As of date  Sysdate  No Valid record as of specific date. Current date – sysdate is a default

Sample query run:
The following is a sample run of the query to list MedDRA equivalents for SNOMED-CT concept whose concept ID is entered as input. Sample parameter substitution is highlighted in blue:
SELECT  D.concept_id               Snomed_concept_id,
        D.concept_name             Snomed_concept_name,
        D.concept_code             Snomed_concept_code,
        D.concept_class            Snomed_concept_class,
        CR.relationship_id,
        RT.relationship_name,
        A.Concept_id               MedDRA_concept_id,
        A.Concept_name             MedDRA_concept_name,
        A.Concept_code             MedDRA_concept_code,
        A.Concept_class            MedDRA_concept_class
FROM   vocabulary.concept_relationship  CR,
       vocabulary.concept               A,
       vocabulary.concept               D,
       vocabulary.relationship          RT
WHERE  CR.relationship_id = 239
AND    CR.concept_id_2    = A.concept_id
AND    CR.concept_id_1    = 312327
AND    CR.concept_id_1    = D.concept_id
AND    CR.relationship_id = RT.relationship_id
AND    sysdate BETWEEN CR.valid_start_date AND CR.valid_end_date
 Output:
Output field list:
 Field  Description
 SNOMED-CT_Concept_ID  Concept ID of SNOMED-CT concept entered as input
 SNOMED-CT_Concept_Name  Name of SNOMED-CT concept
 SNOMED-CT_Concept_Code  Concept code of SNOMED-CT concept
 SNOMED-CT_Concept_Class  Concept class of SNOMED-CT concept
 Relationship_ID  Identifier for the type of relationship
 Relationship_Name  Description of the type of relationship
 MedDRA_Concept_ID  Concept ID of matching MedDRA concept
 MedDRA_Concept_Name  Concept name of matching MedDRA concept
 MedDRA_Concept_Code  Concept code of matching MedDRA concept
 MedDRA_Concept_Class  Concept class of matching MedDRA concept

Sample output record:
 Field  Value
 SNOMED-CT_Concept_ID  312327
 SNOMED-CT_Concept_Name  Acute myocardial infarction
 SNOMED-CT_Concept_Code  57054005
 SNOMED-CT_Concept_Class  Clinical finding
 Relationship_ID  239
 Relationship_Name  SNOMED-CT to MedDRA equivalent (OMOP)
 MedDRA_Concept_ID  35205180
 MedDRA_Concept_Name  Acute myocardial infarction
 MedDRA_Concept_Code  10000891
 MedDRA_Concept_Class  Preferred Term
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